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See below for other meetings and events! We would like to invite you to join the U. The purpose of the meetings is to encourage free discussion and collaboration by users of Pb, At, and Ac and to address issues or questions amongst peers. Stay tuned for more details on the forums in an upcoming announcement. In addition to the program overview and forums above, the DOE IP has organized and will moderate a technical session on Tuesday, June 25th from to pm.

The session will be delivered by postdoctoral researchers and early career scientists from the Isotope Program, discussing their own exciting and significant studies into the production of medically relevant isotopes. The Ac half-life of The DOE IP has completed accelerator production campaigns for Ac approximately every other month since early , and the program will adjust batch frequency as needed to meet future market demand and ensure a reliable and abundant supply for research efforts and clinical trials.

In addition to our booth presence, numerous researchers conducting invaluable production research on medical isotopes with DOE IP support will present at this event, including keynote speaker Dr. Saed Mirzadeh, distinguished staff scientist and technical lead for the medical isotope research and production program at Oak Ridge National Laboratory.

TAT11 will provide information on the newest developments in preclinical studies, clinical experiences, dosimetry and instrumentation, quality assurance, regulatory, targeting, radiochemistry, and nuclide production and supply. For more information or to register for TAT11 visit www. We are pleased to announce that small quantities of berkelium Bk , einsteinium Es and fermium Fm isotopes will be available through the U.

These isotopes are of particular interest to heavy element chemistry and nuclear physics research. For further inquiries about the availability of these isotopes, please contact the NIDC at the contact information below. LEAF became the newest facility addition to the DOE IP in and will begin producing high specific activity copper Cu to facilitate the development of new therapeutic theranostic agents for cancer treatment. In addition, the DOE IP invites researchers to evaluate initial test batches of the material at no cost excluding dispensing and shipping ; interested parties are encouraged to contact the NIDC for more information.

Copper has a number of desirable properties for therapeutic applications such as a sustainable production route, appropriate half-life and beta emission energy, and the ability to use companion diagnostic agents labelled with the chemically identical copper PET radioisotope for assessing patient suitability and likely response.

Most notably, a clinical trial NCT recently commenced to study the effectiveness of an Atlabelled radiopharmaceutical in treating patients with leukemia and lymphoma. Due to its short half-life, distribution of At is limited, with longer delivery times resulting in increased decay. Runde move on, we are also excited for him as he takes on this new chapter in his career; yesterday was Dr. Runde's last day with the Program. Runde joined the DOE Isotope Program in as leader of the Los Alamos National Laboratory isotope team, where he increased operational capabilities, implemented process improvements, and increased productivity.

Runde became the NIDC Associate Director for Production and Customer Relations, where he continued to coordinate radioisotope accelerator production and became the primary point of contact for accelerator-produced radioisotope customers In and , he worked directly with the management team of the DOE Isotope Program while on a detail assignment at DOE, providing essential expertise to the federal management of the program.

His passion for making medical radionuclides available for therapy and diagnosis of life-threatening diseases, as well as isotopes for critical energy and homeland security applications, has bolstered the DOE Isotope Program's role in these applications. We sincerely thank Dr.

Runde for his dedicated and impactful service. Effective immediately, Ms. Runde's responsibilities regarding customer relations for accelerator-produced radioisotopes. Sikes can be reached at sikeskg ornl. It has a theoretical specific activity of 5. The DOE IP has completed accelerator production campaigns for Ac approximately every other month since early , and the program plans to continue this schedule depending on market demand to ensure a reliable and abundant supply for research efforts and clinical trials.

Additional batches can be produced upon demand. For further inquiries about the availability of Ac, please contact Dr. Read about the latest developments in the U. Department of Energy Isotope Program's product availability, university partnerships, facility improvements, staff news, and other notable activities. Highlights for this issue include:. Eligibility for the FOA is limited to domestic institutions of higher education and domestic non-profit research institutions. National Laboratory participation is limited to a sub-awardee category.

If you have any questions, please contact Dr. Balkin science. Eligible candidates must have a bachelor's degree in communications, journalism, public relations, English, or a science-related field and a minimum of 5 years of experience in communications and outreach support for a scientific or technical organization, marketing or public relations firm, or similar entity.

Interested parties are welcome to apply here. A new batch of beryllium-7 Be-7 will be available through the U. Quotation requests for Be-7 may be placed using the National Isotope Development Center's product catalog. For further inquiries about the availability of Be-7, please contact Dr.


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The DOE IP has completed accelerator production campaigns for Ac every other month since early , and the program plans to continue the bi-monthly schedule depending on market demand to ensure a reliable and abundant supply for research efforts and clinical trials. Quotation requests for Ac may be placed using the National Isotope Development Center's product catalog. Interested and serious individuals are invited to apply for this permanent federal position at:. This individual will be responsible for the performance of these facilities, strategic planning associated with the facilities and the development of new production capabilities within the program.

The Program Manager for Isotope Facilities will focus on the operations of Isotope Facilities within the scope of the program, including their needed resources and productivity. This individual will be responsible for the performance of these facilities, strategic planning associated with the facilities, and the development of new production capabilities within the program. The position will be advertised on July 9th at www. Interested and serious individuals are invited to apply. This person would be reporting directly to me and would be a member of the federal team managing the DOE Isotope Program.

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Dennis Phillips retired. The Program Manager for Isotope Facilities will focus on the operations of Isotope Facilities within the scope of the isotope program, including their needed resources and productivity. This Program Manager will be responsible for the performance of these facilities, strategic planning associated with the facilities and the development of new production capabilities within the program.

Serious inquiries may contact me at the information below. Actinium Ac is a promising medical radioisotope well known for its cancer-fighting abilities. Limited production capabilities, however, have curbed its potential as a widespread therapy option. A new U. An invitation to this open event from Dr. Department of Energy's DOE isotope production, university partnerships, facility improvements, staff news, and other notable center activities.

Department of Energy DOE for their instrumental roles in the campaign to produce the enriched stable isotope ruthenium Ru , last produced in the United States more than 40 years ago. Presented on behalf of Dr. Stephen Binkley, Deputy Director for Science Programs in the Office of Science, these awards express the Department's appreciation for the tremendous effort that this activity demanded, resulting in a significant capability for the Nation and enabling critical nuclear physics research to move forward.

The newly enriched Ru provided scientists at Brookhaven National Laboratory with a sufficient amount to study the properties of quark-gluon plasma, a new form of matter discovered at the lab's Relativistic Heavy Ion Collider that has not existed since the infant universe. Seaborg Award. The prestigious award, sponsored by the ACS Division of Nuclear Chemistry and Technology NUCL , has been presented annually since , recognizing individuals who have made outstanding contributions to the advancement of the science or application of nuclear chemistry and radiochemistry.

Since first arriving at BNL in , Suresh has played a vital role in the conception, development, and market transition of numerous radionuclides used in nuclear medicine. His peers view him as a pioneer for his achievements in the field of theranostics-radiopharmaceuticals capable of both diagnosing and treating cancer and cardiovascular disease, among other serious illnesses. In , Suresh co-founded the World Association of Radiopharmaceutical and Molecular Therapy WARMTH to promote the use of such radionuclide molecular therapy and recently concluded a two-year term as the association's president.

He holds a B. Subject to the availability of funds, the U. Department of Energy Isotope Program DOE IP considers a limited number of proposals to offer travel bursaries for students and postdoctoral trainees to attend domestic and international conferences, meetings, or workshops. All proposals are competitively reviewed, and selections are made based on numerous criteria that align with the DOE IP mission. This notice is to distribute the guidance from the DOE IP on travel bursaries, which can be found in the attached file. Specifically, it provides guidance for both proposal preparation and post-award actions i.

Please direct any questions to Dr. These meetings are being organized by the DOE IP to encourage free discussion and collaboration by users of specific isotopes as well as to provide information on the broader DOE IP portfolio. Details on each meeting are provided below:. Please contact Dr. Wolfgang Runde with any questions. We hope to see you there! This FOA can be found online at the U. Eligibility for the FOA is limited to domestic institutions of higher education, domestic non-profit research institutions, and national laboratories.

The application deadline is June 15, , by P. Eastern Standard Time. If you have any questions please email Dr. Ethan Balkin at Ethan. This was the position vacated by Dr. Dennis Phillips when he retired last year. So please welcome Dr. In addition, I'd like to give the community advance notification of a position that will be advertised in the very near future hopefully in the next few weeks within the DOE Isotope Program.

You must be a U. This is a very important position within our team. I urge you to give this position some thought and to bring qualified candidates to my attention at jehanne. Feel free to contact me for more details. We look forward to receiving applications for the Program Manager for Isotope Facilities in the very near future. In addition, this milestone successfully fulfills a recommendation by the Isotope Subcommittee of the Nuclear Science Advisory Committee for the DOE IP to re-establish a domestic stable isotope enrichment capability.

Due to insufficient quantities of this rare isotope in DOE's inventory or availability from other sources worldwide, a new production campaign at ESIPP was initiated. Ruthenium in naturally occurring Ru metal is only 5. With the Ru, the RHIC nuclear physics experiment will study the dynamics of the quark gluon plasma created in ion collisions in response to electromagnetic fields generated by the colliding ions; the quark gluon plasma is a new form of matter discovered at RHIC and has not existed since the infant universe.

The availability of the Ru makes this research viable. Production of Ru will continue at ESIPP through , then will be followed with production of other stable isotopes approaching critical supply levels. Parties interested in procuring Ru or other stable isotopes can request a quote through the National Isotope Development Center's product catalog. For additional inquiries on Ru availability, please contact the Isotope Business Office.

A positron emitter with a relatively long half-life The half-life of 89 Zr is sufficiently long to assure time for these labeled proteins to reach tumor sites. The most common technique for producing 89 Zr is by bombarding natural Y targets in a cyclotron. The resulting 89 Zr is then purified from the dissolved Y targets. Most commonly, the 89 Zr purification is performed using a hydroxamate resin column, wherein 89 Zr is loaded onto the column from the dissolved Y target in hydrochloric acid HCl , the column is washed with the acid to remove Y, and then the isolated 89 Zr is eluted from the column using 1 M oxalic acid H 2 C 2 O 4.

In this paper, the research team describes a simple, automated fluidic system prototype for the purification of 89 Zr that provides near-real time monitoring of column effluents. In addition, the team demonstrated that a lower concentration of 89 Zr eluent can be used with no decrease in 89 Zr product yield. An advantage of lower isotope product solution strength is that proportionally less buffering salts are required to be added prior to protein labeling, and less additives mean a lowered opportunity for contamination of the isotope product with metals that compete for labeling sites.

The authors performed titrations on several buffered 89 Zr product fractions using deferoxamine to assess product purity and demonstrated purity levels on par with previously reported values. Additional findings are detailed in the full manuscript. This work was funded by the U. Department of Energy Isotope Program. Department of Energy's DOE isotope production, university partnerships, facility improvements, staff news, and more.

Lu is a radioisotope commonly used for research in cancer treatment and has a half-live of 6. The product, Lu chloride solution 0. There is a minimum charge per order of 25 mCi less activity can be ordered, but 25 mCi is the minimum charge. Production and delivery times will be dependent on HFIR's predetermined production cycles. The general specifications of the material are given in the table below.

Additional analytical results are available upon request. Full kegs have a gross weight of approximately 63 kg, which includes 50 kg of heavy water. To ensure product quality, purchases may only be made in full keg quantities. The Department of Energy's Isotope Program DOE IP has set aside two days, Tuesday, November 7 and Wednesday, November 8, , for "one-on-one" meetings with interested commercial customers to discuss isotope supply and demand issues.

The meetings provide an opportunity for the isotope community to discuss issues with the director and managers of the DOE IP. Department of Energy Isotope Program gives viewers a behind-the-scenes look at the production of isotopes critical to everyday applications, particularly in the medical arena.

Stable Isotopes

For instance, researchers across our national laboratory network explain how continuously improving production techniques for radioisotopes like actinium, astatine, lead, and copper directly impacts the accuracy and efficacy of targeted cancer therapies. The video also demonstrates how integrating universities into DOE's network helps to broaden production capabilities and, therefore, more efficiently fulfill end-user requests.

Following several years of constrained supply, the U. Department of Energy Isotope Program has replenished its inventory and is accepting new orders for the radioisotope uranium U , which is most commonly used to prolong the life of flux monitors for nuclear power plants. The available U is recovered via chemical ion-exchange from substantial amounts of aged plutonium housed at the Oak Ridge National Laboratory. The U half-life of , years has a theoretical specific activity of 6. It is sold in oxide U 3 O 8 form.

This announcement is intended to seek information from private companies on their potential isotope needs for the next five years and is not a Request for Proposal RFP or an Invitation for Bid IFB , nor is it to be construed as a commitment by the Government. The Government does not intend to contract on the basis of this request or otherwise pay for any information solicited herein.

This synopsis is to notify the public that the NIDC, on behalf of the IDPRA, seeks information from the community on anticipated needs of isotope products and potential supply shortages in the next five years. The IDPRA seeks this information to better understand the demand for isotopes used in research or commercial applications, including devices such as detectors and calibration sources and gauges that contain isotopes. The information provided in this request form will assist the IDPRA in optimizing production plans in the upcoming fiscal years and in strategically planning the future production of isotopes, gauging future demand, and evaluating and investing in the needs for isotope production technology development.

The NIDC is requesting that companies complete and submit the attached survey form to runde lanl. Information should be submitted even if the potential need for an isotope is somewhat uncertain for the coming years.


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  8. If a specific isotope is not identified or requested by anyone, it may not be considered for production or production development by the IDPRA during fiscal years All information submitted is considered highly business-sensitive and will not be shared or discussed outside the IDPRA. Leonard Mausner is retiring on July Mausner's, who has played a critical role in its operation in support of the U. His conception and implementation of several major facility upgrades helped boost availability of isotopes used in high-priority research and medical applications, and his techniques have since been applied at facilities worldwide, bolstering BNL's reputation in the isotope arena.

    He has also contributed to the development of several medical radionuclides used for therapy and diagnosis of life-threatening diseases. An already remarkable career was topped off last month when Dr. Aside from his research accolades, Dr. His involvement in NCSS will continue into his retirement. Mausner for his dedicated and impactful service, and wish him the best in all his future endeavors. Department of Energy's DOE Isotope Program is pleased to announce a new partnership with the University of Missouri that further strengthens the nation's isotope portfolio.

    The high purity, high specific activity Se will be routinely processed and dispensed from inventory at the MURR. This partnership marks the second agreement first reactor-based production agreement within a network of university facilities that works with the DOE Isotope Program to promote production and availability of high priority isotopes, as recommended in the NSAC-I Long-Range Plan. Consideration of additional university sites to the network is underway. For further information, please contact Dr.

    Wolfgang Runde runde lanl. These alpha-emitters are obtained from Ac cows to produce very high purity products. The cows currently have the capability of producing hundreds of mCi of Ra and Th per month, allowing for the capability to support basic science and pre-clinical research. If you are interested in further information, please contact Dr. Wolfgang Runde at runde lanl. Topics to be covered include alpha emitters e. Ac , theranostic isotopes e. Cu , a programmatic update, and a tribute to Leonard Mausner who will be retiring from Brookhaven National Laboratory. Two other meetings are scheduled to facilitate free discussion and collaboration by users of specific isotopes At and Pb Dates, times, and meeting locations can be found below.

    Wolfgang Runde with any questions runde lanl. The DOE Isotope Program has initiated several efforts to re-establish the production of some selected radioisotopes that have been requested by stakeholders and the user community. These isotopes are in short supply or have been unavailable worldwide. The pharmaceutical industry comprises of companies that are engaged in research, development, manufacture and distribution drugs for human or veterinary use.

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    As well as increasing shareholder value, this contributes significantly to the quality and protection of life and helps make the world a better place. In the past 60 years, innovation and technology have driven huge improvements in global health. Every clinical trial in Austria has to be approved by the Federal Office for Safety in Healthcare and needs a positive opinion of the ethics committee.

    The objective is to prove the effectiveness and tolerability of these forms of treatment and to improve the medical care of future patients. In principle, a distinction is made between clinical trials intervention studies and non-interventional studies. Market Analysis of Global Pharmaceutical Industries. It is expected that the global market declined by 1. Prescription sales excluding generics will rise 4. There is a need to impede serious adverse effects caused by the drugs by enhancing drug targeting through research in pharmacology.

    Drug Metabolite Identification: Stable Isotope Methods

    This market is expected to grow at a compound annual growth rate CAGR of The fast-growing division of the pharmaceutical market includes generics and biologics. Biologics now account for over a third of all new drugs in clinical trials or awaiting FDA approval. Although generics make up only 22 percent of total prescription sales, its share of filled prescriptions has risen from 19 percent in to 88 percent in The research-based pharmaceutical industry is estimated to have spent nearly USD Among all the industrial sectors, the research-based pharmaceutical industry has consistently invested the most in research and development, even in times of economic turmoil and monetary crisis.

    Global brand spending is forecast to increase to USD billion in Healthcare Back Commercialization. Healthcare Commercialization. Biotech The Hub Global Pharma. Clinical Trial Investigators Participate in a Trial. Improve ROI with solutions designed for faster, more informed decisions Global implementation of automation technology for faster insights A partner with over 30 years experience providing drug metabolism support.

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